CDH5 polyclonal antibody
产品名称： CDH5 polyclonal antibody
英文名称： CDH5 polyclonal antibody
产品编号： PAB7871
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDH5.
- Immunogen:
- A synthetic peptide corresponding to amino acids 770-781 of human CDH5.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This sequence has significant homology to the conserved site in rat and mouse, and has less than 50% homology with other cadherins.
- Form:
- Liquid
- Storage Buffer:
- In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:2000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.
Wallez Y, Cand F, Cruzalegui F, Wernstedt C, Souchelnytskyi S, Vilgrain I, Huber P.Oncogene. 2007 Feb 15;26(7):1067-77. Epub 2006 Aug 14.
- 2.
- Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.
Potter MD, Barbero S, Cheresh DA.J Biol Chem. 2005 Sep 9;280(36):31906-12. Epub 2005 Jul 18.
- 3.
- Association of Csk to VE-cadherin and inhibition of cell proliferation.
Baumeister U, Funke R, Ebnet K, Vorschmitt H, Koch S, Vestweber D.EMBO J. 2005 May 4;24(9):1686-95. Epub 2005 Apr 7.
- Entrez GeneID:
- 1003
- Protein Accession#:
- P33151
- Gene Name:
- CDH5
- Gene Alias:
- 7B4,CD144,FLJ17376
- Gene Description:
- cadherin 5, type 2 (vascular endothelium)
- Omim ID:
- 601120
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq
- Other Designations:
- 7B4 antigen,VE-cadherin,cadherin 5, type 2,cadherin 5, type 2, VE-cadherin (vascular epithelium),cd144 antigen,endothelial-specific cadherin,vascular endothelial cadherin
- Related Disease