CDKN2A monoclonal antibody, clone 5A8A4,3G8D12
产品名称： CDKN2A monoclonal antibody, clone 5A8A4,3G8D12
英文名称： CDKN2A monoclonal antibody, clone 5A8A4,3G8D12
产品编号： MAB8309
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant CDKN2A.
- Immunogen:
- Recombinant protein corresponding to truncated human CDKN2A.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In ascites
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:2000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.
Bai F, Pei XH, Godfrey VL, Xiong Y.Mol Cell Biol. 2003 Feb;23(4):1269-77.
- 2.
- Tumor suppression by Ink4a-Arf: progress and puzzles.
Lowe SW, Sherr CJ.Curr Opin Genet Dev. 2003 Feb;13(1):77-83.
- 3.
- The INK4a/ARF network in tumour suppression.
Sherr CJ.Nat Rev Mol Cell Biol. 2001 Oct;2(10):731-7.
- Applications
- Western Blot (Recombinant protein)
- Western blot analysis using CDKN2A monoclonal antibody, clone 5A8A4, 3G8D12 (Cat # MAB8309) against truncated CDKN2A recombinant protein.
- Entrez GeneID:
- 1029
- Gene Name:
- CDKN2A
- Gene Alias:
- ARF,CDK4I,CDKN2,CMM2,INK4,INK4a,MLM,MTS1,TP16,p14,p14ARF,p16,p16INK4,p16INK4a,p19
- Gene Description:
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
- Other Designations:
- CDK4 inhibitor p16-INK4,OTTHUMP00000021147,OTTHUMP00000021148,cell cycle negative regulator beta,cyclin-dependent kinase inhibitor 2A,cyclin-dependent kinase inhibitor p16,multiple tumor suppressor 1
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Alzheimer Disease
- Alzheimer disease
- Aneuploidy
- Asthma
- Ataxia telangiectasia
- Atherosclerosis
- Atherosclerosis
- Barrett Esophagus
- Bile Duct Neoplasms
- Birth Weight
- Brain Ischemia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Carcinoma
- Carcinoma, Basal Cell